RNASE3 and chronic rhinosinusitis: However, high serum ECP concentrations in patients with chronic rhinosinusitis without allergic rhinitis were found in Kim’s study.28 Studies have revealed that the levels of ECP in nasal secretions are considerably higher than those in the serum.29 We speculated that ECP may show its effect on the local site without joining the circulation, so priority should be given to determining ECP levels in nasal secretions over those in the serum.