ICAM1 and synovitis: Synovitis frequently develops prior to structural damage to the joints, and its presence is linked to the advancement of OA.16 Tumor Necrosis Factor (TNF) and Inter-Cellular Adhesion Molecule 1 (ICAM-1), which are significant pro-inflammatory cytokines, affects the systemic inflammatory response and have recently been linked to the ABO gene by genome-wide research.