A decrease in BNP helps judge the prognosis, and a favorable prognosis[a rapid decrease in BNP often indicates.8 More than 19 million people suffer from sepsis each year, which is defined as life-threatening acute organ dysfunction secondary to infection, such as infection and heart failure that affect each other and promote its exacerbation.9 Cardiac hypofunction is often caused by sepsis because sepsis affects the calcium ion transport function of myocardial cells, resulting in reduced contractility, enlarged heart, and reduced stroke volume and left ventricular ejection index.10 The gene discussed is NPPB; the disease is Sepsis.