IL12B and rheumatoid arthritis: The IL12B gene polymorphism presents a strong genetic predisposing factor to RA while studies establishing association of intronic SNPs of IL12B gen with RA have been conducted in Chinese (rs2243115, rs3212227),9 Egyptian (rs3212227),10 Bulgarian (rs17860508, rs3212227),11 and Polish population (rs3212227, rs17860508).12 There has not been much research on the IL12B gene variants in Pakistan with reference to RA.