INS and brain edema: However, several studies have contested that the administration of low-dose (0.05 IU/kg/h) insulin shows non-inferiority to the standard dose, with the earlier achieving a similar resolution time of ketoacidosis with fewer complications [20–22]: decreased insulin infusion rate gradually reduces glucose levels in the blood, increasing the sodium concentration level in the serum and reducing the effective plasma osmolality [23]; the plasma osmolality change rate is an important factor associated with cerebral edema-the major cause of mortality among pediatrics with DKA [2,24,25].