In the present study, we investigated 91 inflammatory factors, 309 metabolite ratios, 1,091 blood metabolites, 205 gut microbiome pathways and 207 gut microbiome taxa and discovered that N-formylmethionine levels, cystatin D levels, ketogluconate metabolism and N10-formyl-tetrahydrofolate biosynthesis may possess mediating functions in the process of AN-sepsis. Here, CST5 is linked to Sepsis.