Among the 91 inflammatory factors, 309 metabolite ratios, 1,091 blood metabolites, 205 gut microbiome pathways and 207 gut microbiome taxa examined, N-formylmethionine levels, cystatin D levels, ketogluconate metabolism, and N10-formyl-tetrahydrofolate biosynthesis were found to be associated with the causal association between AN and sepsis. This evidence concerns the gene CST5 and Sepsis.