In sensory neurons of mice (51), in rat dorsal root ganglion neurons (52) and in human corneal epithelial cells (53), activation of TRPV-1 unleashes pro-inflammatory substances like substance P (sP) and interleukin 6 (IL-6) respectively, key players in COVID-19 pathophysiology, with reported elevations correlating with illness severity (54, 55). This evidence concerns the gene IL6 and COVID-19.