IL1A and carotid atherosclerosis: Similarly, our previous studies have also shown that specific single nucleotide polymorphisms (SNPs) in genes related to inflammation and endothelial function and high-risk interaction among HABP2 rs7923349, ITGA2 rs1991013, IL1A rs1609682, and NOS2A rs8081248, the interaction between ITGA2 rs4865756 and HABP2 rs7923349, and interaction among ITGA2 rs1991013, IL1A rs1609682, and HABP2 rs7923349 were associated with carotid plaque vulnerability (10), carotid stenosis and IMT (14, 15), and increased risk of carotid atherosclerosis (16), respectively.