Further research into the genetic susceptibility from meta- and mega-analyses highlights mutations and gene sets in chromosome 11 p15 region (chr11p15), and gene sets in potassium channels (Kv3, Kir 6.2, and SUR subunit) which are highly, if not exclusively, expressed in the brain cerebellum, were enriched for association with anxiety and depression. The gene discussed is ABCC8; the disease is major depressive disorder.