In the Cancer Genome Atlas (TCGA) database (Ualcan.path.uab.edu/analysis), we analyzed the expression of HE4 in lung cancer: Compared with adjacent normal tissues, HE4 was significantly overexpressed in LUAD patients (n = 515), whereas there is opposite expression in LUSC (n = 503) (Fig. 1C). This evidence concerns the gene WFDC2 and cancer.