Tumor-associated macrophages are associated with tamoxifen resistance in postmenopausal breast cancer patients [39], study shows that sodium/glucose cotransporter 1 (SGLT1) overexpression drives the highly glycolytic phenotype of tamoxifen-resistant breast cancer cells where enhanced lactic acid secretion promotes M2-like tumor-associated macrophages polarization via the hypoxia-inducible factor-1α/signal transducer and activator of transcription-3 pathway [40]. Here, STAT3 is linked to breast carcinoma.