Finally, chemoresistance towards 5-FU in CRC cells was associated with reduced protein levels of E-cadherin and higher protein expression levels of fibronectin (a mesenchymal marker) and EMT-TF’s, Twist1, Zinc-finger E-box-binding homeobox 1 (Zeb1) and Zinc-finger E-box-binding homeobox 2 (Zeb2) [14]. The gene discussed is ZEB1; the disease is colorectal carcinoma.