CXCL16 and neoplasm: Meanwhile, we detected broad chemokine and receptor interactions between malignant cells and other cells (Fig. 7B), including CCR6-CCL20, CXCR3-CCL20 and CXCR6-CXCL16 (Romero et al., 2020), suggesting the chemoattraction potential of malignant ductal cells in the formation of a tumor-promoting microenvironment.