KRAS and familial pancreatic carcinoma: As for our study, pathway analysis found known PDAC driver pathways, such as KRAS, MYC, MAPK and WNT signaling pathways (Australian Pancreatic Cancer Genome Initiative et al., 2012; Australian Pancreatic Cancer Genome Initiative et al., 2015; Witkiewicz et al., 2015; Raphael et al., 2017), enriched in the five subtypes, which supported their tumor origin.