As depicted in UMAP plots, THBS2, THBS4 and COMP were primarily expressed by fibroblasts, while THBS3 was predominantly expressed by tumor cells and fibroblasts, and THBS1 was predominantly expressed by fibroblasts, monocyte-macrophages and endothelial cells (Fig. 6B-F). The gene discussed is THBS3; the disease is neoplasm.