By contrast, during the in vivo infection with NNV, our data show certain regulation of il17 receptors, mainly up-regulations of il17ra, il17rb, or il17rd in the European sea bass brain, the target tissue and susceptible species, coinciding with increments of the il17c1 and il17d ligands (González-Fernández et al. 2020). The gene discussed is IL17RD; the disease is infection.