For example, RA has been reported to activate p50/p65 induced Vcam1 expression in mouse neuroepithelial cells, which are precursors for neurons and glia,43 while in human dermal microvascular epithelial cells RA has been shown to inhibit TNF-α induced VCAM1 expression.45 The gene discussed is VCAM1; the disease is rheumatoid arthritis.