Concurrently, an immunosuppressive factor called TIME facilitates tumor growth by depleting T cells that infiltrate the tumor, activating immune checkpoint genes including VISTA, TIM‐3, and LAG‐3 that hinder immune response, and inhibiting immune cells such as Tregs, TAMs, and myeloid‐derived suppressor cells (MDSCs).220. Here, LAG3 is linked to neoplasm.