146, these genes play a role in the control of cell surface receptors for cytokines, growth factors, signal transduction molecules, and TFs, as well as epigenetic regulators, regulators of the cell cycle, and regulators of apoptosis in different cancers (Figure 2). According to Ref. 147, TSGs are typically thought of as negative regulators of cell development that are effective upon invasive and metastatic ability. Additionally, TSGs and proto‐OCGs are crucial for the growth of myeloid cells. Acute myeloid leukemia (AML) can be caused by a mutation in this type of cell.148. The gene discussed is CD177; the disease is acute myeloid leukemia.