On the multivariable logistic regression analysis (Table 3), presence of DCIS (OR, 3.975 [95% CI: 1.448–10.908], p = 0.007), luminal B (odds ratio [OR], 5.076 [95% CI: 1.401–18.391], p = 0.013), HER2-enriched subtype (OR, 10.949 [95% CI: 3.262–36.747], p < 0.001), multifocal or multicentric lesions(OR, 2.467 [95% CI: 1.067–5.706], p = 0.035) were independently associated with higher odds of imaging-pathological discordance. The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.