• The miR-17-92 cluster was significantly elevated in MYC-amplified AS compared to AS without amplification and the control group.• In AS with MYC amplification, miR-18a and miR-19a from the miR-17-92 cluster down-regulated THBS1 and CTGF gene mRNA expression.• By inhibiting clusterin production via the TGF-b signaling pathway, the miR-17-92 cluster promotes angiogenesis.• CCN family member CTGF was downregulated in MYC-amplified AS, suggesting its role in angiogenesis suppression in this sarcoma subtype. The gene discussed is TGFB1; the disease is sarcoma.