• Integration of expression profiles with miRNA expression data indicated probable important miRNA-gene regulator connections for each sarcoma subtype.• The anticipated targets HMCN1, NKX2-2, SCNN1G, and SOX2 were increased in Ewing’s sarcoma and fibromatosis samples, where miR-182-5p is downregulated. The gene discussed is HMCN1; the disease is Ewing sarcoma.