One of the most studied antioxidant compounds is mitoquinone (MitoQ), which exerts direct antioxidant action by scavenging superoxide, peroxyl, and peroxynitrite ROS.44 In an AD transgenic mouse model expressing three human mutant genes, APP, PSEN1 and tau, MitoQ treatment showed improved behavioral phenotype. Here, APP is linked to Alzheimer disease.