A recent study showed that knockdown of transient receptor potential vanilloid 4(TRPV4), a nonselective Ca2+ channel, can reduce the concentration of pro-inflammatory cytokines including IL-18, COX-2, and 5-LOX in PD mice.107 The calcium channel blocker carvedilol has been demonstrated to decrease the release of pro-inflammatory cytokine TNF-α IL-2 and IL-6.108 Many research groups also reported that VGCCs and RyRs play an important role in neuroinflammation.68,109. Here, TNF is linked to Parkinson disease.