CMA1 and metabolic disease: While histamine was positively correlated to the depth of the invasion, serum tryptase had no correlation with various grades of OSCC.17,18 Moreover, as mast cells are associated with collage metabolic disorders, it is suggested that they play similar role in pathogenesis of OSMF and labelled it as a collagen metabolic disorder.19 Nonetheless, the literature gap shows need to understand the role of chymase and histamine in pathogenesis of OSMF and its malignant transformation.