Finally, our findings here with TRPM4 may also be relevant for understanding the neuroprotective actions of icilin in mouse models of multiple sclerosis and seizures (Pezzoli, Elhamdani et al. 2014, Ewanchuk, Allan et al. 2018, Moriyama, Nomura et al. 2019). This evidence concerns the gene TRPM4 and multiple sclerosis.