Our group and others identified sine oculis homeobox homolog 1 (SIX1) as a novel mediator in lung fibrosis promoting release of pro-fibrotic mediators by alveolar epithelial cells.30–32 Further, SIX1 has also been implicated in asthmatic lung fibrosis31,32 and in liver fibrosis defined by excessive myofibroblast activation and ECM deposition33. Here, SIX1 is linked to Hepatic fibrosis.