Lung fibrosis is an important complication of SSc that is typically observed following onset of skin fibrosis and while epithelial and fibroblast based mechanisms are most highly studied, the contribution of the adipocyte to fibrotic process is not fully known.34 However, whether SIX1 plays a role in skin fibrosis in SSc is not known, in particular how adipocyte SIX1 regulates dermal fibrosis remains under investigated. Here, SIX1 is linked to systemic sclerosis.