SIX1 and cancer: In healthy adults, SIX1 is negligibly expressed in most tissues.36 Perhaps the most well-studied role of SIX1 in adulthood is in the context of cancer where it is a critical regulator of trans-differentiation of pre-cancerous cells into mesenchymal cells with metastatic features.37–41 Although SIX1 transcript expression has been identified in healthy subcutaneous adipose tissue42, to date it’s exact role in adipose tissue biology remains poorly investigated.