Recently, it was demonstrated that in vivo SIX1 overexpression in mouse hepatocytes exacerbate diet-induced liver inflammation, metabolic disruption, and hepatic steatosis, and activates liver-specific receptors to induce de novo lipogenesis.44 This work is founded upon the fundamental and newly developing understanding of the roles of SIX1, particularly in the realm of lipolysis and the release of pro-fibrotic factors that regulate dermal fibrosis. This evidence concerns the gene SIX1 and Hepatic steatosis.