Given the importance of MG phagocytosis in AD pathogenesis42,43 and the possible role of PICALM in clathrin-mediated endocytosis in non-MG cells32,44, we hypothesized that the LOAD risk allele of rs10792832 affects IMG phagocytosis through the reduced PICALM expression. The gene discussed is PICALM; the disease is Alzheimer disease.