HPRT1 and parasitic infectious disease: This enzyme catalyzes the conversion of hypoxanthine or guanine to inosine or guanosine monophosphate, and is important in generating purine nucleotides through the purine salvage pathway.[40] Prior reports describe targeting HGPRT with tailor synthesized nucleoside analogs,[41] as well as by pentamidine, 1,3-dinitroadamantane, acyclovir and acyclovir analogs.[42, 43] The focus of these reports is on treatment of parasitic diseases, and higher activity is reported in HGPRT from parasites compared to that from human.