LEP and metabolic syndrome: Several studies found suggestive linkage evidence on this region for relevant traits including fasting glucose (Loos et al., 2003), circulating leptin (Kissebah et al., 2000), T2D (Lindgren et al., 2002), coronary artery disease (Gao et al., 2014), and metabolism syndrome (Kissebah et al., 2000; Zhang et al., 2013).