INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, exercise decreases the number of CD8+ T cells and macrophage infiltration in obesity-related adipose tissue, while enhancing the secretion of anti-inflammatory cytokines IL6 and IL10 and shifting macrophage phenotype from M1 to M2 in the subcutaneous fat of high-fat diet mice, resulting in improved insulin sensitivity [205].