We further delved into the signals that upregulated Piezo‐1 in VSMC by probing for α‐actinin 2, as we have previously shown that this actin fiber crosslinker activates Piezo‐1 expression in VSMC, thereon modulating VSMC responses in aortic aneurysms (Qian et al., 2022). This evidence concerns the gene PIEZO1 and aortic aneurysm.