The molecular pathogenesis of HCC involves the dysregulation of multiple signalling pathways, including Wnt/ß-Catenin, RAS/MAPK, PI3K/AKT/mTOR, TP53/cell cycle, IGFR, and MET, which is related to point mutations, copy number variations, epigenetic alternations, tumour suppressor inactivation and so on [4]. This evidence concerns the gene TP53 and hepatocellular carcinoma.