We revealed hotspot mutations in 111 Chinese patients with HCC, and the genomic mutation frequency of CTNNB1 (21.6% vs. 22.6%), AXIN1 (14.4% vs. 13.7%), RB1 (11.7% vs. 11.9%) in our cohort was not significantly different from previous reports [28]. Here, RB1 is linked to hepatocellular carcinoma.