The results, based on LC–MS analysis, indicated that FN1, VWF, IGHV3-23, FGB, IGLV3-1, PRG4, PRDX1, and SACS were highly expressed in the EVs derived from the serum of patients with AVN compared with the serum EVs of the control group. This evidence concerns the gene PRDX1 and avascular necrosis.