Notably, in COAD (OS: n = 448, p = 0.030, Fig. 3A), KIRC (OS: n = 531, p = 0.012, Fig. 3B), Brain Lower Grade Glioma (LGG) (OS: n = 524, p < 0.001, Fig. 3C), and THYM (OS: n = 118, p = 0.038, Fig. 3D), elevated expression of TRAF1 was associated with poorer patient outcomes. Here, TRAF1 is linked to central nervous system cancer.