Our data indicate that (1) repeated UV irradiation can lead to cognitive deficits and reduced neurogenesis; (2) chronic UV exposure elevates dopamine levels in the skin, adrenal glands, and brain; (3) UV exposure causes cognitive alterations by acting through the dopamine D1 receptor; and (4) the administration of dopamine in mice replicates the cognitive impacts observed with UV exposure. The gene discussed is DRD1; the disease is Cognitive impairment.