To investigate luminal TG2 expression under an inflammatory condition, WT and TG2IEC-KO mice were treated with interferon-gamma (IFN-γ), a cytokine that induces an enteropathy with tissue-remodeling features similar to celiac disease,6 and thus potentially reflecting increased TG2 expression due to higher cell turnover or increased amount per cell. This evidence concerns the gene IFNG and celiac disease.