IFNG and Abnormal intestine morphology: To investigate luminal TG2 expression under an inflammatory condition, WT and TG2IEC-KO mice were treated with interferon-gamma (IFN-γ), a cytokine that induces an enteropathy with tissue-remodeling features similar to celiac disease,6 and thus potentially reflecting increased TG2 expression due to higher cell turnover or increased amount per cell.