Higher levels of TXA2s associated with allergic sensitization, blood eosinophils, and Feno in COPSAC2010, which suggests a link to type-2 inflammation that is a common pathway in some subtypes of AD and asthma.53 In VDAART, we observed that increased LTE4 was associated with allergic sensitization and increasing total IgE, which validates the association between urinary LTE4 and type-2 inflammation biomarkers in a previous study of adults and adolescents3 and further proposes a role of LTE4 in the inception of type-2 inflammation in early childhood. This evidence concerns the gene IGHE and asthma.