MAPT and neurodegenerative disease: Approximately 84% of genes known to be associated with human neurodegenerative disease have a zebrafish counterpart (92), including SMA1, HTT, Tau, TDP43, and APP. Zebrafish have a number of characteristics that make them versatile animal models for 3D/4D imaging, including their rapid development ex utero and large reproductive capacity, which facilitates experiments at larger scale and with greater statistical power than can be achieved with rodents.