It is reported that mechanical stimuli, inflammation, and hypoxia all can induce the upregulation of LOXL2 [11–13], and as a consequence, the pathological process of fibrosis or remodeling in various diseases, such as heart failure, cancer, pulmonary arterial hypertension, and organ fibrosis (e.g. liver, lung, and renal), are aggravated [11, 14–18]. The gene discussed is LOXL2; the disease is heart failure.