For example, TWAS risk genes APOC2, BIN1, SLC24A4, BCL3, RELB, and CLPTM1 are known risk genes for family history of AD, AD biomarker measurement, and mental or behavioral disorders; TWAS risk genes MAPT, WNT3, and LINC02210 were related to white matter microstructure measurement; TWAS risk genes MAPT, TUBB, PPP5C, FCER1G, INPP5D, NDUFS2, NDUFAF6, and BCL3 are common risk genes for complete blood cell count, leukocyte count, myeloid white cell count, and eosinophil count. The gene discussed is RELB; the disease is Alzheimer disease.