Through protein-protein interaction network analysis [29] with these 141 significant TWAS risk genes, we detected gene networks comprised of known AD risk genes such as APOC2, BIN1, CASS4, MS4A4A, MS4A6A, SLC24A4, and MAPT and additional risk genes that are not mapped in the GWAS Catalog. This evidence concerns the gene MS4A4A and Alzheimer disease.