These three pathways included the key known AD risk genes MS4A4A, SLC24A4, MS4A6A, BIN1, and CASS4. The fourth pathway was ADP-ribosylation factor-like protein 17, and LRRC37A/B like protein 1, C-terminal, which included TWAS risk genes LRRC37A2, ARHGAP27, and ARL17A on chromosome 17. The gene discussed is BIN1; the disease is Alzheimer disease.