TNF and steatosis: Despite the marked steatosis, iVP16LXRα mice did not present an increased hepatic inflammatory signature, as indicated by the halved expression of Tumour Necrosis Factor α (Tnfα), Tumour Growth Factor β (Tgfβ) and Interleukin 6 (Il6) as well as the decreased level of the macrophage marker F4/80 (Fig. 5I-J).