The Kaplan-Meier survival analysis revealed that the low expression level of ABCG5 and ABCG8 -possible due to a decreased activation of LXR- correlates with a decreased survival probability in humans with HCC (p = 0.0253 and p = 0.0325, respectively; Fig. 7D-E). The gene discussed is ABCG8; the disease is hepatocellular carcinoma.