Despite this net uncoupling between cholesterol accumulation and Lxr transcriptome in the liver tumours of iVP16LXRα mice, these animals showed an induction of the genes involved in the cholesterogenesis pathway, especially of Squalene Epoxidase (Sqle), whose overexpression in MASH-HCC tumours is associated with poor patient outcomes [28, 29], whereas no changes were detected in the mRNA level of Hmgcr (Fig. 6H). This evidence concerns the gene HMGCR and hepatocellular carcinoma.