Intriguingly, in tumour tissue of WD-fed mice, while the expression of Nr1h3 was significantly induced (Fig. 1L), the mRNA levels of its target genes involved in cholesterol excretion Abcg5/8 and de novo lipogenesis (Srebp1c, Fasn, Scd1) were not changed between the two groups of mice (Fig. 1M-N). This evidence concerns the gene NR1H3 and neoplasm.