Then, we investigated the relationship between lncRNA MEG3 and miR-143-3p in asthma by transfecting control-siRNA, MEG3-siRNA, inhibitor control, miR-143-3p inhibitor, MEG3-siRNA + inhibitor control, and MEG3-siRNA + miR-143-3p inhibitor to HASMCs. This evidence concerns the gene MEG3 and asthma.