CpG oligodeoxynucleotides and budesonide synergistically alleviated the Th17/Th2 imbalance in CS-associated asthmatic mice by modulating IL-23 secretion and blocking TSLP, but whether CpG oligodeoxynucleotides alone still have the above effects and whether the drugs can be extended to human applications requires further study [57]. This evidence concerns the gene TSLP and Cowden syndrome 1.