Concerning the direct cytotoxicity of astroglia-produced proinflammatory cytokines, including TNFα [8–10], to RGCs in glaucoma and a prolonged amplification cycle of the glia-driven neurodegenerative inflammation stimulated by downstream NF-κB activation [6], such an astroglia-targeting immunomodulatory approach can provide long-term protection to these precious neurons. Here, NFKB1 is linked to glaucoma.