Patients with schizophrenia show decreased nAChR expression compared with controls in postmortem brain,52 and abnormal assembly or trafficking of these receptors in schizophrenia is implied.53 Importantly, these receptors regulate the release of many neurotransmitters including glutamate,54,55 which is an excitatory neurotransmitter essential for proper brain function. Here, CHRNA4 is linked to schizophrenia.