Initial memory impairment. MMSE age 47 was 7/30, with severe verbal, visual and general memory, and attention impairment on psychometry. CT of the brain demonstrated moderate generalized atrophy. Post‐mortem confirmation of AD neuropathologic change (see Figure 3). Confirmed carrier of PSEN1 P436S. APOE status ε3/ε3. Here, APOE is linked to Alzheimer disease.