APOE and memory impairment: Initial memory impairment. At age 46 they developed apraxia and dyscalculia. On examination age 48 there was apraxia, myoclonus, increased tone in the lower limbs with hyper‐reflexia and downgoing plantar responses, and no parkinsonism or cerebellar signs. MRI at age 48 demonstrated generalized atrophy including the hippocampi (Figure 1B). At age 49 they developed word‐finding difficulty and a stutter. Confirmed carrier of PSEN1 P436S. APOE status ε2/ε3.