TRMT2B, NSUN4, TFB1M, MRM3, MRM2, TRMT112, TRMT61B, TRMT1, PUS1, METTL8, GTPBP3, MTO1, YRDC, NSUN2, and TRMT6 were upregulated in grade III glioma, whereas METTL6 was downregulated in grade II glioma in the TCGA cohort (Fig. S4A). This evidence concerns the gene TRMT6 and central nervous system cancer.