Two types of lamins have been identified: type A and type B. In recent years, in-depth studies have shown that the protein nuclear lamin B1 (LMNB1) was closely associated with human diseases such as cell aging and malignant tumors, and traces of LMNB1 have been detected in multiple tumor sites in the human body (Fig. 1). Here, LMNB1 is linked to neoplasm.