Garvalov et al. and Jia et al. [4, 7] found that LMNB1 expression levels were reduced in lung cancer patients; additionally, the loss of a single LMNB1 allele can activate the RET/p38 signaling pathway through the recruitment of multi-combing inhibitory complex 2 (PRC2), thus promoting the development and metastasis of lung cancer. The gene discussed is LMNB1; the disease is lung cancer.