Xiao et al. [64] inhibited LEF1 expression in Caco-2 cells, a human cloned colorectal adenocarcinoma cell line, by the shRNA method, and the results of this study supported that LEF1 downregulation suppressed the expression of LMNB1, thus inhibiting the viability and proliferation of colorectal adenocarcinoma cells. Here, LEF1 is linked to colorectal adenocarcinoma.