The latter is conceptually linked to cardiovascular risk factors, such as hypertriglyceridemia [74] or hypertension [75], commonly associated with obesity, as well as medications (e.g., insulin/oral hypoglycemics and antidepressants/antianxiety drugs) that collectively may have partly accounted for changes in 5hmC levels in human Obese-MSCs. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.