Continuous infusion of the anti-IL-6 antibody, or an isotype control antibody, was initiated at two different timepoints, with the first being at 10 or 12 days after tumor inoculation (Fig. 4a, b), a stage when the AP has increased IL-6 and AP neurons show elevated activity (Fig. 3b–d), but cachexia has not yet started. This evidence concerns the gene IL6 and neoplasm.