Lastly, specific suppression of the activities of Gfral+ neurons, which partially overlap with Il6ra+ cells in the AP (Fig. 1g, h; Supplementary Fig. 6c, d) and are involved in the effects of Il6ra suppression (Fig. 6d), also attenuates cancer-associated cachectic phenotypes and AP network hyperactivity. This evidence concerns the gene IL6R and cancer.