GFRAL and cancer: Notably, compared with the GFP mice with tumor, the TeLC mice with tumor exhibited increased food intake at the late stage of cancer progression (Fig. 9d) and increased muscle mass at the endpoint (Fig. 9e), to levels comparable to the GFP sham group (i.e., mice that expressed the virally delivered GFP in Gfral+ neurons and received saline injection instead of tumor inoculation).