Thus, we investigated whether DSP as a rich source of polyphenol could significantly improve glycemic indices including fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), HOMA-IR, HOMA-B, QUICKI, lipopolysaccharide (LPS), and s-RAGE, as well as other parameters associated with oxidative stress in people with T2DM for eight weeks. The gene discussed is AGER; the disease is type 2 diabetes mellitus.