BRCA1 and neoplasm: Nevertheless, compared to other non-BRCA-associated tumors, BTC displays a high-frequency of biallelic LoF, both in the setting of gBRCA2 alterations (65%) and sBRCA1/2 (61%).32 Moreover, BTC carrying biallelic LoF in BRCA1/2 has been shown to yield among the highest magnitude of HRD-scores (odd ratio 21.5), which was confirmed also for other HR-/DDR-genes.30,32 As such, BTC represent a tumor type for which investigating the status of HR-/DDR-genes might yield significant rationale, if being studied for allele-specific variants.