CDKN2A and cancer: NK cells activated, monocytes, Tregs, B cells naive, T cells CD8, T cells CD4 memory resting, and macrophages M2 were lower in CDKN2A-MUT or DEL patients’ tumor tissue than in CDKN2A-WT patients, implying an immune cold tumor immune microenvironment in TCGA pan-cancer with CDKN2A VAR (Fig. 6A).