Next, in the MSK-IMPACT cohort with ICIs treatment, significant associations of CDKN2A MUT, DEL, and ALT with OS were not found in esophagogastric cancer, breast cancer, melanoma, and NSCLC except for bladder cancer (Figure S2B; Fig. 3C and D), in contrast to the MSK-MetTropism cohort (Fig. 2F, Figure S1B and E). This evidence concerns the gene GPT and urinary bladder carcinoma.